AAWSAP DIRD, Technological Approaches to Controlling External Devices, March 2010

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localized in a manner where the top site will be below the cortical surface. The electrode
assembly was then wrapped with Gel Foam (Pfizer, I nc. , New York) and then cemented
with dental acrylic (Reference 47). Once the experiment was concluded, precise location
of the cortical arrays was obtained by passing currents though the electrodes to cause
micro-lesioning, then post-mortem examination of brain slices could locate the lesions
and reconstruct the precise 3-D position of the electrodes (Figure 7). This test provided
an initial understanding of brain activity and the ability to utilize microelectrodes to
localize specific neural regions.
Sample slices from all implants
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Figure 7. Histology and Electrode Tracks. The left panel shows Nissl-stained coronal sections of sample slices
from all animals D1-D4 showing electrode tracks or lesion marks for all seven implantations. The black line marks
the boundary between the upper and lower layers. The right panel shows seven coronal sections arranged rostro­
caudally, as indicated by the schematic, for one implant (D4Leh) showing alternating lesions and electrode tracks
which were used to reconstruct site locations. (Reference 47)
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